- What genes underlie differences in sleep patterns between people?
- What are the molecular mechanisms underlying sleep disorders?
- Why do we sleep?
- What molecular pathways cause changes in daily biological rhythms such as morningness-eveningness preference?
- How does clock gene variation impact human physiology, behavior and disease?
- What genetic variation influences timing of gene expression?
- What maternal and fetal genetic factors cause preeclampsia?
- How does preeclampsia relate to cardiometabolic risk factors and outcomes?
- What genetic factors contribute to post-partum hemorrhage?
- Does sleep and circadian rhythm disruption cause, mark or result from chronic disease?
- What mechanisms connect sleep, circadian rhythms and disease?
- Do sleep or behavioral timing interventions prevent or ameliorate disease features?
- What are the molecular links between circadian rhythms and metabolism?
- How does insomnia contribute to development of cardio-metabolic disease?
- How does the MTNR1B diabetes risk gene link circadian rhythms to type 2 diabetes?
- What are the mechanistic links between sleep, circadian rhythms and Alzheimer’s disease?
- Can sleep be a longitudinal biomarker of early Alzheimer’s disease?
- What are the causes and consequences of circadian rhythm disruption in neurodegenerative disease?
