Saxena Lab

Our Projects

Circadia Study is a novel direct-to-participant cohort study focused on the genetics of individuals with advanced and delayed sleep phase disorder.
The project aims to define the genetic basis of subjectively and objectively assessed chronotype, characterize the functional molecular, cellular, and physiologic consequences of causal genes, and variants, and dissect shared genetic relationships between chronotype and metabolic disease outcomes.
This project aims to discover common and rare variants for preeclampsia, identify molecular pathways altered before clinically defined disease using multi-omics analysis, and use PE polygenic scores to predict maternal morbidity and future maternal cardiovascular health.