Saxena Lab

Our Projects

This project aims to identify genes and pathways at GWAS loci for insomnia symptoms in humans, test the consequence of loss-of-function of Drosophila orthologs on sleep and cardiac function, and test the impact of perturbed sleep on cardiovascular function in humans and Drosophila.
Links to Cardiometabolic Disease Research AreaGenetics of Sleep Research Area
The project aims to define the genetic basis of subjectively and objectively assessed chronotype, characterize the functional molecular, cellular, and physiologic consequences of causal genes, and variants, and dissect shared genetic relationships between chronotype and metabolic disease outcomes.
Links to Cardiometabolic Disease Research AreaGenetics of Circadian Rhythms Research Area
This project aims to discover common and rare variants for preeclampsia, identify molecular pathways altered before clinically defined disease using multi-omics analysis, and use PE polygenic scores to predict maternal morbidity and future maternal cardiovascular health.
Genetics of Adverse Pregnancy Outcomes Research AreaLinks to Cardiometabolic Disease Research Area