Chronic fatigue syndrome has a prevalence of about 0.2% in the population and is found to have a heritability of 10-40% based on family studies. However, little is known about its genetic basis. Genetic approaches leveraging large biobanks offer opportunities for gene discovery unbiased to known biology that should provide insights into the biological underpinnings and possible genetic links with long COVID. Meta-analysis across global biobanks with genomic data and links to health records will enhance gene discovery, risk prediction, and subtyping of disease across diverse populations and help to prioritize therapeutic targets.
Co-PIs: Richa Saxena, Hanna Ollila