This recall by genotype study aims to test the impact...Read More
Genetics of Sleep
- What genes underlie differences in sleep patterns between people?
- What are the molecular mechanisms underlying sleep disorders?
- Why do we sleep?
This project aims to identify genes and pathways at GWAS loci for insomnia symptoms in humans, test the consequence of loss-of-function of Drosophila orthologs on sleep and cardiac function, and test the impact of perturbed sleep on cardiovascular function in humans and Drosophila.
This recall by genotype study aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
Genetic approaches leveraging large biobanks offer opportunities for gene discovery unbiased to known biology that should provide insights into the biological underpinnings and possible genetic links with long COVID.